A long-standing question in in vitro hemocompatibility research is how long should an experiment continue to find useful results? We have also received this question quite often from our customers. In an effort to answer this, we compared a low and a high activating reference material in our own in vitro circulation model (Haemobile). After circulation we evaluated the degree of thrombogenicity, platelet function, inflammatory response, coagulation, and hemolysis. We concluded that 60 minutes was the optimal incubation time to discriminate between the low and high activating reference materials.
The publication can be found via the link below: